Publications

Inhibiting the cGAS-STING pathway in myeloid cells effectively improves myocardial healing related to TET2 deficiency-induced DNA damage response

Published in 2024

Species: Mouse |

Sample: Cell Lysate |

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A G-quadruplex stabilizer, CX-5461 combined with two immune checkpoint inhibitors enhances in vivo therapeutic efficacy by increasing PD-L1 expression in colorectal cancer

Published in 2023

Species: Human, Mouse |

Sample: Cell Culture |

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Computational design of constitutively active cGAS

Published in 2023

Species: E. Coli |

Sample: Cell Culture |

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Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease

Published in 2023

Species: Mouse |

Sample: Cell Culture |

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MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

Published in 2023

Sample: Cell Lysate |

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

Published in 2023

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Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity

Published in 2023

Species: Mouse |

Sample: Supernatant |

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Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS

Published in 2023

Species: Human |

Sample: Supernatant |

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The balance between gasdermin D and STING signaling shapes the severity of schistosome immunopathology

Published in 2023

Species: Mouse |

Sample: Cell Lysate |

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The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response

Published in 2023

Species: Human |

Sample: Cell Lysate |

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ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP

Published in 2022

Species: Mouse |

Sample: Cell Culture |

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cGAS exacerbates Schistosoma japonicum infection in a STING-type I IFN-dependent and independent manner

Published in 2022

Species: Worm |

Sample: Supernatant |

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Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

Published in 2022

Species: Mouse |

Sample: Supernatant |

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Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis

Published in 2022

Species: Garlic |

Sample: Cell Lysate |

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Pseudomonas aeruginosa Induces Interferon-beta Production to Promote Intracellular Survival

Published in 2022

Species: Mouse |

Sample: Cell Culture |

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Stalled replication fork protection limits cGAS-STING and P-body-dependent innate immune signalling

Published in 2022

Species: Human |

Sample: Cell Culture |

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cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing

Published in 2021

Species: E. Coli |

Sample: Cell Lysate |

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ER-directed TREX1 limits cGAS activation at micronuclei

Published in 2021

Species: Human |

Sample: Cell Lysate |

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G-quadruplex binders as cytostatic modulators o innate immune genes in cancer cells

Published in 2021

Species: Human |

Sample: Cell Lysate |

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Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2′-O-methyl gapmer oligonucleotides

Published in 2021

Species: Human |

Sample: Cell Culture |

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